Journal article
Analysis of ex vivo drug response data of Plasmodium clinical isolates: The pros and cons of diferent computer programs and online platforms
G Wirjanata, I Handayuni, SG Zaloumis, F Chalfein, P Prayoga, E Kenangalem, JR Poespoprodjo, R Noviyanti, JA Simpson, RN Price, J Marfurt
Malaria Journal | Published : 2016
Abstract
Background: In vitro drug susceptibility testing of malaria parasites remains an important component of surveillance for anti-malarial drug resistance. The half-maximal inhibition of growth (IC50) is the most commonly reported parameter expressing drug susceptibility, derived by a variety of statistical approaches, each with its own advantages and disadvantages. Methods: In this study, licensed computer programs WinNonlin and GraphPad Prism 6.0, and the open access programs HN-NonLin, Antimalarial ICEstimator (ICE), and In Vitro Analysis and Reporting Tool (IVART) were tested for their ease of use and ability to estimate reliable IC50 values from raw drug response data from 31 Plasmodium fal..
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Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
The study was funded by the Wellcome Trust (Senior Research Fellowship in Clinical Science 091625 to RNP), the National Health and Medical Research Council (Project Grant 1023438 to RNP and JM), and the Swiss National Science Foundation (Fellowship for Advanced Researchers to JM). SZ was supported under an Australian National Health and Medical Research Council (NHMRC) Centre of Research Excellence grant, ID# 1035261, awarded to the Victorian Centre for Biostatistics (ViCBiostat).